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  1. Chiral switch - Wikipedia

    • A chiral switch is a chiral drug that has already approved as racemate but has been re-developed as a single enantiomer. The term chiral switching was introduced by Agranat and Caner in 1999 to describe the development of single enantiomers from racemate drugs. For example, levofloxacin is a chiral switch of racemic ofloxacin. The essential principle of a chiral s… 展开

    The concept

    The chiral switch concept is illustrated in the diagram. This chiral switch is from (±)-ibuprofen to (S)-(+) … 展开

    Advantages

    There are several possible potential benefits to chiral switching or chiral specific drugs. These include:
    1. An improved (less complex, more selective) pharmacodynamic profile
    2. A higher … 展开

    Regulatory environment

    The roles of regulatory agencies also continue to evolve with respect to the development of chiral switches. An interesting concept brought up in the FDA policy is that of "bridging studies". When a sponsor/innovat… 展开

     
  1. Putting chirality to work: the strategy of chiral switches

    2002年10月1日 · The strategy of enantiomeric pairs of patents of single enantiomers — E 1 and E 2 — in a chiral switch consists of two patents claiming simultaneously that E 1 and E 2 are pharmacologically ...

  2. Racemic mixture - Wikipedia

  3. Chirality - Wikipedia

    In chemistry, chirality usually refers to molecules. Two mirror images of a chiral molecule are called enantiomers or optical isomers. Pairs of enantiomers are often designated as "right-", "left-handed" or, if they have no bias, "achiral".

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  5. Chiral Switch: Between Therapeutical Benefit and …

    2022年1月24日 · The term chiral switch refers to the replacement on the market of a previously approved racemate with its single enantiomer version. The potential advantages of chiral switch can be related to a higher therapeutic …

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  7. Chiral switches bring new twist to photonics - Nature

  8. A chiral switch: balancing between equilibrium and non …

  9. The Quest for Secondary Pharmaceuticals: Drug …

    2023年1月17日 · The current Perspective introduces the drug repurposing/chiral-switches combination strategy, overviewing representative cases of chiral drugs that have undergone this combination: ketamine, flurbiprofen, fenfluramine, …

  10. Chiral switches - The Lancet