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- Hypoxic-ischemic encephalopathy (HIE) is a brain injury that occurs when your brain doesn’t get enough blood and oxygen. This can permanently change how your brain functions. HIE usually affects newborns who had a difficult birth, but it can also affect older children and adults who experience severe respiratory distress like drowning.my.clevelandclinic.org/health/diseases/hypoxic-ischemic-encephalopathy-hie
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