Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and …
2021年9月12日 · Toll-like receptors (TLRs) are the important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity.
Toll-like receptor - Wikipedia
TLR signaling is divided into two distinct signaling pathways, the MyD88-dependent and TRIF-dependent pathway.
Toll-like receptors activation, signaling, and targeting: an …
2019年12月12日 · The present review summarizes the structure, characterizations, and signaling of TLRs and their regulators, as well as describes the implication of TLRs in many diseases with a brief idea about the inhibitors that target TLR signaling pathways.
Toll-Like Receptor Signaling and Its Role in Cell-Mediated …
2022年3月3日 · This review provides an overview of TLR signaling pathways and their regulators and discusses how TLR signaling, directly and indirectly, regulates cell-mediated immunity. In addition, we also discuss how TLR signaling is critically important in the host’s defense against infectious diseases, autoimmune diseases, and cancer.
Decoding Toll-like receptors: Recent insights and perspectives in ...
2024年4月9日 · TLRs activate common and specific signaling pathways to shape immune responses. Recent studies have shown the importance of post-transcriptional regulation in TLR-mediated inflammatory responses. Despite their protective functions, aberrant responses of TLRs contribute to inflammatory and autoimmune disorders.
Toll-Like Receptor Signaling Pathways - PMC - National Center …
2014年9月25日 · Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the transcription factors NF-κB and IRFs, which dictate the outcome of innate immune responses.
TLR signaling | Cell Death & Differentiation - Nature
2006年1月20日 · This review outlines the recent advances in our understanding of TLR-signaling pathways and their roles in immune responses. Further, we also discuss a new concept of TLR-independent...
Toll-like receptor signalling | Nature Reviews Immunology
2004年7月1日 · Stimulation of Toll-like receptor 4 (TLR4) facilitates the activation of two pathways: the MyD88 (myeloid differentiation primary-response protein 88)-dependent and MyD88-independent pathways.
Toll-like Receptor Signaling - Cell Signaling Technology
Pathway Description: Toll-like receptors (TLRs) recognize distinct pathogen-associated molecular patterns and play a critical role in innate immune responses. They participate in the first line of defense against invading pathogens and play a significant role in inflammation, immune cell regulation, survival, and proliferation.
Toll-like receptor signaling pathways - PubMed
2014年9月25日 · TLR signaling appears to be divergent and to play important roles in many aspects of the innate immune responses to given pathogens. In this review, we describe recent progress in our understanding of TLR signaling regulation and its contributions to host defense.