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  1. The Ran (Ran-related or Ras-like nuclear) protein is the single member of the Ran subfamily, and the most abundant small GTPase in the cell. Like the other small GTPases, Ran functions as a molecular switch, converting between the active GTP-bound and inactive GDP-bound conformations.

    What are Ran GTPases? - National University of Singapore

    www.mbi.nus.edu.sg/mbinfo/what-are-ran-gtpases/
    www.mbi.nus.edu.sg/mbinfo/what-are-ran-gtpases/
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    What are ran GTPases?
    The Ran (Ran-related or Ras-like nuclear) protein is the single member of the Ran subfamily, and the most abundant small GTPase in the cell. Like the other small GTPases, Ran functions as a molecular switch, converting between the active GTP-bound and inactive GDP-bound conformations.

    What are Ran GTPases? - Mechanobiology Institute, National University

    mbi.nus.edu.sg
    What is the role of the small GTPase Ran?
    The small GTPase Ran has roles in multiple cellular processes, including nuclear transport, mitotic spindle assembly, the regulation of cell cycle progression and nuclear assembly. The past year has seen a remarkable unification of these different roles with respect to the effectors and mechanisms through which they function.

    The Ran GTPase: Theme and Variations - ScienceDirect

    sciencedirect.com
    Is ran a druggable GTPase?
    To date, Ran has been studied in a few cancers including breast and ovarian cancers, however, as reported here, it is most likely that this GTPase is involved in other tumor types, and this should be further investigated. Ran is now proposed as a promising therapeutic target, and some recent studies have shown that this GTPase is druggable.

    Ran GTPase: A Key Player in Tumor Progression and Metastasis

    ncbi.nlm.nih.gov
    How does Ran GTPase promote human pancreatic cancer proliferation?
    Deng L, Lu Y, Zhao X, Sun Y, Shi Y, Fan H, Liu C, Zhou J, Nie Y, Wu K, Fan D, and Guo X. Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins.

    What are Ran GTPases? - Mechanobiology Institute, National University

    mbi.nus.edu.sg
    Which GTPase is a Ras-related nuclear protein?
    Ran (Ras-related nuclear protein) GTPase is a member of the Ras superfamily. Like all the GTPases, Ran cycles between an active (GTP-bound) and inactive (GDP-bound) state.

    Ran GTPase: A Key Player in Tumor Progression and Metastasis

    ncbi.nlm.nih.gov
    Is Ran GTPase associated with local invasion and metastasis of renal cell carcinoma?
    I. High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma. Int. J. Cancer. 2008;122:2391–2397. doi: 10.1002/ijc.23400. [PubMed] [CrossRef] [Google Scholar] 97. van Zijl F., Krupitza G., Mikulits W. Initial steps of metastasis: Cell invasion and endothelial transmigration. Mutat. Res.

    Ran GTPase and Its Importance in Cellular Signaling and Malignant

    ncbi.nlm.nih.gov
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    Wikipedia
    https://en.wikipedia.org › wiki › Ran_(protein)

    Ran (protein) - Wikipedia

    Ran's intrinsic GTPase-activity is activated through interaction with Ran GTPase activating protein (RanGAP), facilitated by complex formation with Ran-binding protein (RanBP). GTPase-activation leads to the conversion of RanGTP to RanGDP, thus closing the Ran cycle. Ran can diffuse freely within the cell, but … 展开

    Overview

    Ran (RAs-related Nuclear protein) also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the 展开

    Interactions

    Ran has been shown to interact with:
    • KPNB1,
    • NEK9,
    • NUTF2 展开

    See also

    • GTPase
    • importin
    • mitosis
    • nuclear envelope
    • nuclear transport
    • RGPD5 展开

    Function 图像
    概览 图像
    Function

    Ran cycle
    Ran exists in the cell in two nucleotide-bound forms: GDP-bound and GTP-bound. RanGDP is converted into RanGTP through the action of RCC1, the nucleotide exchange factor for Ran. RCC1 is also known as RanGEF … 展开

    Regulation

    The expression of Ran is repressed by the microRNA miR-10a. 展开

    External links

    • ran+GTP-Binding+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
    • Patel SS. "Animations of nuclear transport factors, including Ran (1 of 2 pages)". Nuclear Transport Animations. Archived from 展开

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  4. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Ran GTPase: A Key Player in Tumor Progression and Metastasis

  6. Mechanobiology Institute, National University of Singapore
    https://www.mbi.nus.edu.sg › mbinfo › w…

    What are Ran GTPases? - National University of …

    网页2023年11月30日 · Ran GTPase is a small GTPase that controls nucleocytoplasmic transport, mitosis, nuclear envelope formation and other cellular processes. Learn how Ran GTPase switches between GTP …

    标记:
    Ran GTPase
    Ran Protein
    Small GTPase
    National University of Singapore
  7. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Ran GTPase: A Key Player in Tumor Progression and Metastasis

    标记:
    Ran GTPase
    Publish Year:2020
    10.3389/fcell.2020.00345
    Published:2020
  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Ran GTPase and Its Importance in Cellular Signaling and Malignant ...

    标记:
    Ran GTPase
    Ran Protein
    Published:2023/02
  9. Nature
    https://www.nature.com › scitable › topicpage › ...

    Coordination of Cell Cycle Events by Ran GTPase

    标记:
    Ran GTPase
    Small GTPase
    Ran Cycle
  10. Nature
    https://www.nature.com › articles

    Targeting small GTPases: emerging grasps on previously ... - Nature

    标记:
    Small GTPase
    Guowei Yin
    Signal transduction
  11. Nature
    https://www.nature.com › articles

    Ran promotes membrane targeting and stabilization of …

    网页2019年6月17日 · Ran stabilizes and co-localizes with RhoA. Ran, a member of the Ras GTPase family, has been demonstrated to control numerous cellular processes of cancer, including cell proliferation and tumor...

    标记:
    Bleach Transwell Membrane
    Rhoa Cancer Cell Migration Invasion
    Ran Gtpase Rho
  12. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    The Ran GTPase: Theme and Variations - ScienceDirect

    标记:
    Ran Gtpase Activating Protein 1
    Non Hydrolyzable Gtp with Ran Gdp
  13. MDPI
    https://www.mdpi.com

    Ran GTPase and Its Importance in Cellular Signaling …

    网页2023年2月4日 · Ran’s GTPase hydrolyzes GTP into GDP [35,37,38]. RanGAP1, RanBP1, and RanBP2 increase the hydrolysis rate of Ran-GTPase [1,39], and RCC1 regulates the GDP-GTP exchange . During …

    标记:
    Ran Gtpase Activating Protein 1
    Phenotype