Radafaxine - Wikipedia
网页Radafaxine (developmental code GW-353,162; also known as (2S,3S)-hydroxybupropion or (S,S)-hydroxybupropion [1]) is a norepinephrine–dopamine reuptake inhibitor (NDRI) which was under development by GlaxoSmithKline in the 2000s for a variety of different indications but was never marketed. [2]
Manifaxine - Wikipedia
网页Manifaxine (developmental code name GW-320,659) is a norepinephrine–dopamine reuptake inhibitor developed by GlaxoSmithKline through structural modification of radafaxine, an isomer of hydroxybupropion and one …
Radafaxine: Uses, Interactions, Mechanism of Action - DrugBank …
网页2016年10月20日 · Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major.
Substrate binding and inhibition mechanism of norepinephrine ...
网页2024年8月14日 · Structures of human NET in the apo state and bound to meta-iodobenzylguanidine and radafaxine provide insights into the mechanism of substrate recognition and orthosteric inhibition of hNET.
The Noradrenergic Action in Antidepressant Treatments: …
网页2010年12月14日 · Hydroxybupropion is its main metabolite (Radafaxine), but it also has many other metabolites eliminated through renal excretion. Maximum concentration is reached in 2–3 h and the steady state in 5–8 days.
Radafaxine Hydrochloride - DrugBank Online
网页Radafaxine Hydrochloride | DrugBank Online. for detailed drug and target data for your pharmaceutical research. Explore detailed drug information packages to support your research & drug discovery. Increase scalability & security by streamlining data sharing & analysis in the cloud.
Radafaxine - Wikiwand
网页Radafaxine (developmental code GW-353,162; also known as (2S,3S)-hydroxybupropion or (S,S)-hydroxybupropion) is a norepinephrine–dopamine reuptake inhibitor (NDRI) which was under development by GlaxoSmithKline in the 2000s for a variety of different indications but was never marketed.
Radafaxine | C13H18ClNO2 | CID 9795056 - PubChem
网页Radafaxine | C13H18ClNO2 | CID 9795056 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
RADAFAXINE - National Center for Advancing Translational …
网页2021年3月15日 · Radafaxine (GW353162, ( )-(2S,3S)-2-(3-chlorophenyl-3,5,5-trimethyl-2-morphinol) or S,S-hydroxybupropion) is an active metabolite of bupropion. It acts as an inhibitor of the dopamine transporter. Radafaxine was investigated for the treatment of depression however, development was discontinued.
The slow and long-lasting blockade of dopamine ... - ScienceDirect
网页2005年3月15日 · The significant correlation between plasma and DAT blockade suggests that plasma concentration of radafaxine is a good surrogate marker for monitoring radafaxine delivery to the brain. In this study, a 40-mg dose of oral radafaxine was devoid of any observable behavioral or cardiovascular effects.
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