The molecular structure of mammalian primary cilia revealed by …
网页2020年9月28日 · Primary cilia are microtubule-based organelles that are important for signaling and sensing in eukaryotic cells. Unlike the thoroughly studied motile cilia, the three-dimensional...
Primary Cilium | Learn Science at Scitable - Nature
网页Nature Education 3 (9):54. What is a primary cilium? Learn how an organelle can be both a sensing organ and a transport machine. Aa Aa Aa. Eukaryotic flagella and cilia have long been...
The primary cilium - PMC - National Center for Biotechnology …
网页2014年1月1日 · The primary cilium is an antenna-like organelle that plays a vital role in organ generation and maintenance. It protrudes from the cell surface where it receives signals from the surrounding environment and relays them into the cell.
The Mechanics of the Primary Cilium: An Intricate Structure with ...
网页2012年1月1日 · The primary cilium is a non-motile singular cellular structure that extends from the surface of nearly every cell in the body. The cilium has been shown to play numerous roles in maintaining tissue homeostasis, through regulating signaling pathways and sensing both biophysical and biochemical changes in the extracellular environment.
Physiological and Pathophysiological Aspects of Primary Cilia—A ...
网页2020年7月14日 · The physiological structure and functioning of the Primary Cilium are prerequisites for proper Shh pathway which is responsible for an adequate skeletal development, tissue patterning and thus an ordered cartilage and bone growth.
The molecular structure of mammalian primary cilia revealed …
网页Primary cilia are microtubule-based organelles that are important for signaling and sensing in eukaryotic cells. Unlike the thoroughly studied motile cilia, the three-dimensional architecture and molecular composition of primary cilia are largely unexplored.
Primary cilia as dynamic and diverse signalling hubs in ... - Nature
网页2023年4月18日 · This Review examines the structural and functional diversity of primary cilia, their dynamic regulation in different cellular and developmental contexts and their disruption in disease.
Primary Cilia: A Closer Look at the Antenna of Cells - Cell Press
网页2020年12月21日 · A recent study reports the three-dimensional structure of a primary cilium with unprecedented clarity. The results highlight the architectural differences with motile cilia and provoke a reassessment of the relationship between the ciliary cytoskeleton and microtubule-based transport in cilia.
The Primary Cilium as the Cell's Antenna: Signaling at a Sensory …
网页2006年8月4日 · Almost every vertebrate cell has a specialized cell surface projection called a primary cilium. Although these structures were first described more than a century ago, the full scope of their functions remains poorly understood.
The Cilium: Cellular Antenna and Central Processing Unit - Cell …
网页2016年9月12日 · Primary cilia are microtubule-based organelles that are formed from a centriolar anchor, known as the basal body, and extend from the apical surface of most mammalian cells (Box 1).