NPM1 - Wikipedia
网页NPM1 is associated with nucleolar ribonucleoprotein structures and binds single-stranded and double-stranded nucleic acids, but it binds preferentially G-quadruplex forming nucleic acids. It is involved in the biogenesis of ribosomes and may assist small basic proteins in their transport to the nucleolus.
Significance of NPM1 Gene Mutations in AML - PMC - National …
网页2021年9月17日 · NPM1 is the most commonly mutated gene in adult AML, present in approximately 25–35% of patients . It is less frequent in children with approximately 8% of childhood AML patients harbouring an NPM1 mutation .
The Role of Nucleophosmin 1 (NPM1) Mutation in the Diagnosis …
网页2022年1月13日 · Nucleophosmin (NPM1) is a multifunctional protein with both proliferative and growth-suppressive roles in the cell. In humans, NPM1 is involved in tumorigenesis via chromosomal translocations, deletions, or mutation.
Current status and future perspectives in targeted therapy of NPM1 ...
网页2022年8月25日 · NPM1 mutations are the most common genetic alteration in acute myeloid leukemia (AML), detected in about 30–35% of adult AML and more than 50% of AML with normal karyotype.
NPM1 Gene - GeneCards | NPM Protein | NPM Antibody
网页2024年8月6日 · NPM1 (Nucleophosmin 1) is a Protein Coding gene. Diseases associated with NPM1 include Acute Myeloid Leukaemia With Myelodysplasia-Related Features and Leukemia, Acute Myeloid. Among its related pathways are Transport of the SLBP independent Mature mRNA and Signaling by ALK fusions and activated point mutants.
How I diagnose and treat NPM1 -mutated AML - American …
网页2021年2月4日 · Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional protein, occur in approximately one-third of adult acute myeloid leukemia (AML).
NPM1 -mutated acute myeloid leukemia: from bench to bedside
网页2020年10月8日 · NPM1 is the most commonly mutated gene in adult acute myeloid leukemia (AML; ∼30% of cases). 2 The most distinguishing feature of NPM1 mutants is their aberrant cytoplasmic localization, 3 which led to the discovery of NPM1 mutations by immunohistochemistry (IHC), prior to the next-generation sequencing (NGS) era. 2 …
NPM1 gene - MedlinePlus
网页The NPM1 gene provides instructions for making a protein called nucleophosmin, which is found in a small region inside the nucleus of the cell called the nucleolus. Learn about this gene and related health conditions.
NPM 1 Mutations in AML—The Landscape in 2023 - PMC
网页2023年2月12日 · NPM1mutated AML (NPM1 mut -AML) has been reclassified as a distinct entity in the 2022 World Health Organization (WHO 2022) and European Leukemia Network (ELN 2022) classification on myeloid neoplasm requiring >10% of …
Diagnostic and therapeutic pitfalls in NPM1 -mutated AML
网页2021年4月20日 · Mutations of Nucleophosmin (NPM1) are the most common genetic abnormalities in adult acute myeloid leukaemia (AML), accounting for about 30% of cases. NPM1 -mutated AML has been...