Cadherin-2 - Wikipedia
Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes.
The E-Cadherin and N-Cadherin Switch in Epithelial-to …
2019年9月20日 · The structural difference between E-cadherin and N-cadherin is that E-cadherin binds with the shorter isoform of p120 catenin while N-cadherin binds with the longer isoform. Abbreviations: EC = extracellular cadherin; ctn: catenin.
Cadherin - Wikipedia
N-cadherin takes part in the development of the heart during embryogenesis, especially in sorting out of the precardiac mesoderm. N-cadherins are robustly expressed in precardiac mesoderm, but they do not take a role in cardiac linage.
N-cadherin-mediated adhesion and signaling from development …
N-cadherin plays a critical role in maintaining the structural integrity of the heart by mediating strong adhesion between cardiomyocytes. On the other hand, N-cadherin is expressed in migratory fibroblastic or mesenchymal cells.
Role of Cadherins in Cancer—A Review - PMC - National Center …
2020年10月15日 · N-cadherin is overexpressed in invasive and metastatic breast cancer and induces metastasis by potentiating signaling by the FGF receptor in humans . There are various factors which modulate N-cadherin expression in tumor cells such as TGF-β1, Wnt/β-catenin, EGFR and NF-κB.
N-Cadherin: structure, function and importance in the ... - PubMed
N-Cadherin belongs to a superfamily of calcium-dependent transmembrane adhesion proteins. It mediates adhesion in the intercalated discs at the termini of cardiomyocytes thereby serving as anchor for myofibrils at cell-cell contacts.
N-cadherin adhesive interactions modulate matrix ... - Nature
2016年8月15日 · N-cadherin can alter how the stiffening extracellular microenvironment is interpreted by mesenchymal stem cells, leading to subsequent changes in downstream cell proliferation and...
The cadherin superfamily in neuronal connections and …
2006年11月29日 · Drosophila melanogasterN-cadherin (DN-cadherin) has been shown to be crucial for the formation of axonal connections with target neurons in both the visual and olfactory systems, and also for...
Development of intensiometric indicators for visualizing N-cadherin ...
2022年10月7日 · N-cadherin (NCad) is a classical cadherin that mediates cell–cell interactions in a Ca 2+ -dependent manner. NCad participates in various biological processes, from ontogenesis to higher brain...
N-cadherin in cancer metastasis, its emerging role in …
2018年10月1日 · N-cadherin is a member of the calcium-dependent adhesion molecule family of classical cadherins which directly mediate homotypic and heterotypic cell-cell adhesion. N-cadherin is a classical type I cadherin consisting of 5 extracellular domains linked to a functional intracellular domain.