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A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway in lymphocytes. JAK inhibitors are … 展开
JAK enzymes are part of the JAK/STAT pathway. This signaling pathway transmits chemical signals from the outside of cells, specifically lymphocytes, and into the cell nucleus. Signals relayed by JAK3 aid in the maturation and … 展开
Janus kinase inhibitors can be classed in several overlapping classes: they are immunomodulators, they are DMARDs (disease-modifying antirheumatic drugs), and they are a subclass of 展开
2012Tofacitinib becomes the first JAK inhibitor to be approved by the FDA for rheumatoid arthritis.2017Development of a selective JAK3 inhibitor is ongoing.2019FDA requires a boxed warning for tofacitinib, baricitinib, and upadacitinib to include information about the risks of serious heart-related events, cancer, blood clots, and death.2020EMA recommends that JAK inhibitors should be used in certain people only if no suitable alternative treatments are available.In September 2021, the U.S. Food and Drug Administration (FDA) approved the first JAK inhibitor, ruxolitinib, to treat a skin condition. 展开
Approved compounds
In clinical trials
• Brepocitinib (PF-06700841), dual JAK1/TYK2 inhibitor for plaque psoriasis.
• Cerdulatinib (PRT062070) dual SYK/JAK inhibitor for hematological malignancies. 展开CC-BY-SA 许可证中的维基百科文本 What are JAK inhibitors and how do they work? - Drugs.com
JAK inhibitors are medicines that block immune system signals that cause inflammation and pain in various conditions. Learn about the types, mechanism…
- Janus kinase (JAK) inhibitors are a group of medicines that help block immune system signals i…
When used for the treatment of rheumatoid arthritis, Janus kinase (JAK) inhibitors are part of a wider group of drugs called DMARDs (Disease-Modifying Anti-Rheumatic Drugs). DMARDs help to slow down ongoing joint damage in rheumatoid arthritis.
- Janus kinase (JAK) inhibitors are a group of medicines that help block immune system signals i…
A Comprehensive Overview of Globally Approved JAK Inhibitors
网页2022年5月6日 · Currently, several nonselective JAK inhibitors, including brepocitinib, cerdulatinib, gusacitinib, and momelotinib (Figure 68), are being investigated for their …
- DOI: 10.3390/pharmaceutics14051001
- 已发布: 2022/05
- Publication: Pharmaceutics. 2022 May; 14(5): 1001.
JAK Inhibitors: Uses, Types, Side Effects, and More
网页2024年2月5日 · JAK inhibitors are drugs that can treat various inflammatory diseases, such as rheumatoid arthritis, psoriasis, and alopecia areata. Learn about the different types, dosages, side effects, …
Current and future status of JAK inhibitors - The Lancet
网页JAK inhibitors are drugs that target Janus kinases, which are involved in cytokine signalling and immune responses. They are used to treat various diseases, such as myeloproliferative neoplasms, rheumatoid …
JAK Inhibitors — More Than Just Glucocorticoids | NEJM
网页2021年7月28日 · Among the antiinflammatory agents, JAK inhibitors have the distinct advantage that their low cost and oral administration allows for scalable use in low- and middle-income countries in regimens...
JAK inhibitor selectivity: new opportunities, better drugs?
网页2024年9月9日 · The first JAK inhibitor, ruxolitinib, was approved by the FDA in 2011, followed by tofacitinib in 2012 (refs. 17, 18). Since then, a dozen JAK inhibitors have …
JAK inhibitors: new indication and emerging safety data in 2022
网页2022年12月19日 · JAK inhibitors are here to stay and are showing promise and being studied in a variety of novel indications such as dermatomyositis, giant cell arteritis, …
JAK inhibition as a therapeutic strategy for immune and …
网页2017年12月12日 · In this review, we will discuss one class of drugs, Janus kinase (JAK) inhibitors (jakinibs), briefly discussing the role of JAKs in cytokine signaling, the …
Basic Mechanisms of JAK Inhibition - PMC - National Center for ...
网页2020年6月11日 · jak inhibitors in practice Tofacitinib, baricitinib and, most recently upadacitinib, are each approved for the treatment of RA. In terms of selectivity, …
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