Breast Cancer HER2 Status | What is HER2 Status?
What is HER2 and what does it mean? HER2 is a protein that helps breast cancer cells grow quickly. Breast cancer cells with higher than normal levels of HER2 are called HER2-positive.
HER2 - Wikipedia
The expression of HER2 is regulated by signaling through estrogen receptors. Normally, estradiol and tamoxifen acting through the estrogen receptor down-regulate the expression of HER2.
HER2 positive breast cancer: What it is, diagnosis and treatment
2022年8月22日 · There are two tests used to determine HER2 status: Immunohistochemistry (IHC test): Measures the amount of HER2 on the surface of the cell. Tumors with a score of zero or one are HER2 negative. Two is a borderline diagnosis. If a cell has a …
Tissue Evaluation for HER2 Tumor Marker - StatPearls - NCBI Bookshelf
2024年1月7日 · HER2 expression is a key element of many breast cancers. Tissue evaluation for HER2 tumor marker status necessitates a comprehensive and collaborative approach among healthcare professionals to optimize patient outcomes.
A Comprehensive Review of HER2 in Cancer Biology and …
2024年7月11日 · Human epidermal growth factor receptor 2 (HER2), a targetable transmembrane glycoprotein receptor of the epidermal growth factor receptor (EGFR) family, plays a crucial role in cell proliferation, survival, and differentiation.
Human Epidermal Growth Factor Receptor 2 Testing in Breast …
2023年6月7日 · HER2 testing guidelines have focused on identifying HER2 protein overexpression or gene amplification in breast cancer to identify patients for therapies that disrupt HER2 signaling.
Targeting HER2-positive breast cancer: advances and future …
2022年11月7日 · The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target was a major breakthrough for the treatment of highly aggressive HER2-positive breast cancer, leading...
HER 2: Biology, Detection, and Clinical Implications
HER2 is a membrane tyrosine kinase and oncogene that is overexpressed and gene amplified in about 20% of breast cancers. When activated it provides the cell with potent proliferative and anti-apoptosis signals and it is the major driver of tumor development and progression for this subset of breast cancer.
HER2 in Breast Cancer: ESMO Biomarker Factsheet
HER2 Expression in Breast Cancer. Oncogenic HER2 is overexpressed in 15-20% of primary breast cancers 2 and in approximately 10% of ER-positive breast cancers. 3 Overexpression of HER2 in breast cancer occurs predominantly through amplification of the HER2 gene and is associated with a more aggressive phenotype. 4,5 Amplification of the gene ...
Update on HER2 expression in breast cancer - ScienceDirect
2022年3月1日 · Human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase encoded by the ERBB2 gene. HER2-positive breast cancer, defined as breast cancer with HER2 overexpression as a result of ERBB2 gene amplification, accounts for approximately 15–20% of all invasive breast carcinoma.