Cyclin - Wikipedia
Cyclins are generally very different from each other in primary structure, or amino acid sequence. However, all members of the cyclin family are similar in 100 amino acids that make up the cyclin box. Cyclins contain two domains of a similar all-α fold, the first located at the N-terminus and the second at the C-terminus. All cyclins are ...
What Are Cyclins? - News-Medical.net
2023年7月19日 · The cell cycle is regulated by cyclins, a type of protein that binds and activates cyclin dependent kinases (CDKs).
Cyclin-dependent kinase - Wikipedia
Different cyclin-CDK complexes regulate different phases of the cell cycle, known as G0/G1, S, G2, and M phases, featuring several checkpoints to maintain genomic stability and ensure accurate DNA replication. [1] [5] Cyclin-CDK complexes of earlier cell-cycle phase help activate cyclin-CDK complexes in later phase. [4]
Cyclin D - Wikipedia
Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during G1 and drives the G1/S phase transition. Cyclin D protein is anywhere from 155 (in zebra mussel) to …
Cyclin - an overview | ScienceDirect Topics
Cyclins are a group of stress-sensitive proteins in controlling cell death and survival in DNA damage response. The B-type cyclin, i.e., cyclin B1, is an essential cell cycle component in the regulation of transition from G2 to M phase [127–130].
CDK | Learn Science at Scitable - Nature
Coordinated protein phosphorylation reactions control progression through the cell cycle. Learn how specific complexes of cyclins and cyclin-dependent kinases (CDKs) catalyze these reactions.
Core control principles of the eukaryotic cell cycle - Nature
2022年6月8日 · Cyclin-dependent kinases (CDKs) lie at the heart of eukaryotic cell cycle control, with different cyclin–CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs) 1,2.
Cyclin D as a therapeutic target in cancer - Nature
2011年7月7日 · Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer and is a biomarker of cancer phenotype and disease progression.
Function of cyclins in regulating the mitotic and meiotic cell cycles ...
2008年11月11日 · Several classes of cyclins have been described in mammalian cells, designated A to I, and also T. During the mitotic cell cycle, cyclins from the D-type family (D1, D2 and D3) regulate progression of cells through the G 1 phase. 10 D-type cyclins bind and activate Cdk4 and Cdk6.
Cyclin-dependent kinases | Genome Biology | Full Text
2014年6月30日 · Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.
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