Cremophor EL: the drawbacks and advantages of vehicle ... - PubMed
网页Cremophor EL (CrEL) is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). In contrast to earlier reports, CrEL is not an inert vehicle, but exerts a range of biological effects, some of which have important clinical implications.
Kolliphor EL - Wikipedia
网页Kolliphor EL, formerly known as Cremophor EL, is the registered trademark of BASF Corp. for its version of polyethoxylated castor oil. It is prepared by reacting 35 moles of ethylene oxide with each mole of castor oil.
Cremophor - an overview | ScienceDirect Topics
网页Cremophor EL is specifically used in many liquid preparations of poorly water-soluble drug as a good vehicle to enhance the solubility and consequently bioavailability. They act as a solubilizing agent and as emulsifier in these liquid preparations.
Pharmaceutical Excipients and Drug Metabolism: A Mini-Review
网页2020年11月3日 · Cremophor EL is a heterogeneous non-ionic surfactant made up of castor oil and ethylene oxide with a molar ratio of 1:35 . Cremophor EL helps in solubilizing many hydrophobic drugs which include photosensitizers, immunosuppressive agents, sedatives, anesthetics and anticancer drugs (experimental) .
Investigation of the role of Cremophor RH 40 and Cremophor EL …
网页2024年7月15日 · This study takes a commendable step in this direction by exploring the potential of non-ionic surfactants, Cremophor EL and Cremophor RH40, to inhibit efflux pumps in MDR P. aeruginosa strains, thereby restoring the efficacy of ciprofloxacin.
Cremophor EL 61791-12-6 - MilliporeSigma
网页Cremophor® EL; CAS Number: 61791-12-6; Synonyms: Castor oil polyoxyethylene ether,Ethoxylated castor oil,PEG-35 castor oil,Polyoxyl 35 castor oil,polyoxyl 35 castor oil; find Millipore-238470 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
Cremophor EL - European Journal of Cancer
网页2001年2月26日 · Cremophor EL (CrEL) is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). In contrast to earlier reports, CrEL is not an inert vehicle, but exerts a range of biological effects, some of which have important clinical implications.
Cremophor EL: the drawbacks and advantages of vehicle …
网页2001年9月1日 · Cremophor EL (CrEL) is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). In contrast to earlier reports, CrEL is not an inert vehicle, but exerts a range of biological effects, some of which have important clinical implications.
Clinical pharmacokinetics of paclitaxel monotherapy: an updated ...
网页Due to the hydrophobic nature of paclitaxel, it was originally diluted in the solvent cremophor EL, a poly-oxy-ethylated oil mixed 1:1 with ethanol. This formulation solves one problem, but is associated with hypersensitivity reactions to cremophor EL.
Cremophor - an overview | ScienceDirect Topics
网页Cremophor EL is used for the clinical administration of paclitaxel. The synthetic block copolymer consists of the poly( ε -caprolactone- co -lactide)-PEG (PCLA-PEG) group to form the pattern OSM-PCLA-PEG-PCLA-OSM, where sulfamethazine (OSM) as an end group forms solution in a range of concentrations.