Clozapine | C18H19ClN4 | CID 135398737 - PubChem
网页Clozapine | C18H19ClN4 | CID 135398737 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Clozapine - Wikipedia
网页Chemistry. Clozapine is a dibenzodiazepine [38][39] that is structurally very similar to loxapine (originally deemed a typical antipsychotic). It is slightly soluble in water, soluble in acetone, and highly soluble in chloroform. Its solubility in water is 0.1889 mg/L (25 °C). [5] .
Clozapine: Why Is It So Uniquely Effective in the Treatment of a …
网页2021年7月15日 · Chemical structure of clozapine. Clozapine has a major metabolite, N-desmethylclozapine (NMDC, norclozapine), which has activity comparable to clozapine at the D2 and 5-HT2A receptors as well as at several other receptors [ 10 ]; both the metabolite and parent drug can activate N-methyl-D-aspartate (NMDA) glutamate receptors [ 10 ].
Clozapine, a Fast-Off-D2 Antipsychotic - PMC - National Center …
网页2014年1月1日 · The chemical structure of clozapine facilitates a relatively rapid dissociation from D2 receptors. After short-term occupation of D2 receptors, peak neural activity raises synaptic dopamine, which then displaces clozapine.
Clozapine: An Updated Overview of Pharmacogenetic Biomarkers, …
网页2020年11月11日 · Clozapine chemical structure (IUPAC-C 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine) . This antipsychotic agent has a unique profile for binding to 5-HT 2A/2C receptors, being a serotonin antagonist.
Clozapine chemical structure (IUPAC-C... | Download
网页From a pharmacological point of view, clozapine is a tricyclic dibenzodiazepine that binds to several receptors of the central nervous system ( Figure 4 ). This antipsychotic agent has a unique...
Clozapine - NIST Chemistry WebBook
网页2013年7月6日 · IUPAC Standard InChIKey: QZUDBNBUXVUHMW-UHFFFAOYSA-N. Copy Sheet of paper on top of another sheet. CAS Registry Number: 5786-21-0. Chemical structure: This structure is also available as a 2d Mol file.
Classics in chemical neuroscience: clozapine - PubMed
网页2013年7月17日 · In this Viewpoint, we will showcase the history and importance of clozapine to neuroscience in general, as well as for the treatment of schizophrenia, and review the synthesis, pharmacology, drug metabolism, and adverse events of clozapine.
Classics in Chemical Neuroscience: Clozapine | ACS ... - ACS …
网页2013年7月17日 · Clozapine (CAS No. [5786-21-0]) is a low molecular weight tricyclic benzodiazepine (MW = 326.13) with a lone hydrogen bond donor, three hydrogen bond acceptors, and a cLogP of 3.7. Thus, clozapine conforms to Lipinski’s rules and displays excellent DMPK parameters and CNS penetration (vide infra).
Clozapine | C18H19ClN4 - ChemSpider
网页ChemSpider record containing structure, synonyms, properties, vendors and database links for Clozapine, 5786-21-0, Clozapine (Tautomer)