Chordoma - Pathology - Orthobullets
2021年6月21日 · Learn about chordoma, a malignant tumor of primitive notochordal origin that most commonly occurs in the sacrum and coccyx. Find out the epidemiology, anatomy, histology, differential diagnosis, treatment, complications and prognosis of chordoma.
Chordoma - StatPearls - NCBI Bookshelf - National Center for ...
2023年8月7日 · A chordoma is a low-grade, slow-growing but locally invasive and locally aggressive tumor that is a type of sarcoma. Chordomas arise from remnants of the notochord and occur along the midline spinal axis between the clivus and the …
Chordomas: Histopathological Study in View of Anatomical …
2019年4月4日 · Chordomas are aggressive bone tumors that have a predilection for the axial skeleton including the skull base and spinal/sacral bones. However, the histopathological and clinical differences between skull base chordoma (SBC) and sacral/spinal chordoma (SC) are unclear as previous studies have been focused on patient prognosis and treatment outcome.
Chordoma—Current Understanding and Modern Treatment …
2021年3月4日 · Virchow was the first to characterize the histology of chordoma . He described it as a “physaliphorous” (i.e., vacuolated or bubble-bearing) mass, in reference to the numerous cytoplasmic vacuoles by which it is characterized to this day [ 2 ].
Chordoma | Archives of Pathology & Laboratory Medicine - Allen …
2021年7月28日 · This article summarizes the clinical and pathologic features, molecular pathogenesis, and therapeutic options of chordoma, a rare malignant neoplasm of notochordal origin. It also discusses the differential diagnosis and the …
Chordoma - Libre Pathology
Classic chordoma panel: EMA, AE1/AE3, CAM5.2, vimentin, S-100. Key points: Brachyury is not a commonly stocked antibody. Chordoma will be S100 and epithelial marker positive. Many other items in the DDx will be either S100 or epithelial marker positive. See also. CNS tumours. Parachordoma. References
Chordomas: A review with emphasis on their pathophysiology, pathology …
2020年9月1日 · Chordomas are rare, malignant tumors of notochordal origin that affect the axial skeleton. This article summarizes their histological, immunohistochemical, and genetic features, as well as their differential diagnosis and treatment options.
Chordoma: What It Is, Types, Symptoms & Treatment - Cleveland Clinic
The World Health Organization (WHO) recognizes three distinct types of chordoma based on what the cells look like under a microscope (their histology): Classic/conventional chordoma: This is the most common type (80% to 90% of all cases). It’s …
Chordoma - PubMed
2022年3月1日 · Chordoma is a clinically and histologically unique malignant neoplasm, and numerous diagnostic considerations must be excluded to establish the correct diagnosis. Treatment options have largely been centered on surgical excision with marginal results; however, novel therapeutic options including tar …
Chordomas: A review with emphasis on their pathophysiology, pathology …
Histologically, chordomas, believed to derive from notochordal tissue, characteristically show physaliphorous cells in a myxoid or chondroid matrix. Dedifferentiated and poorly differentiated forms can be observed. Moreover, a grading scale for chordomas has been proposed. Cytokeratin, EMA, S100, and brachyury are expressed by most chordomas.
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