Butyrylcholinesterase - Wikipedia
网页Butyrylcholinesterase is a prophylactic countermeasure against organophosphate nerve agents. It binds nerve agent in the bloodstream before it can exert effects in the nervous system.
Butyrylcholinesterase: A Multifaceted Pharmacological Target …
网页Butyrylcholinesterase is a serine hydrolase that catalyzes the hydrolysis of esters in the body. Unlike its sister enzyme acetylcholinesterase, butyrylcholinesterase has a broad substrate scope and lower acetylcholine catalytic efficiency.
Emerging significance of butyrylcholinesterase - PMC
网页2024年3月3日 · Butyrylcholinesterase (BChE; EC 3.1.1.8), an enzyme structurally related to acetylcholinesterase, is widely distributed in the human body. It plays a role in the detoxification of chemicals such as succinylcholine, a muscle relaxant used in …
Neurobiology of butyrylcholinesterase | Nature Reviews …
网页2003年2月1日 · Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase has unique enzymatic...
Butyrylcholinesterase as a prognostic marker: a review of the ...
网页2012年9月6日 · Butyrylcholinesterase (BChE) is an α-glycoprotein synthesized in the liver. Its serum level decreases in many clinical conditions such as acute and chronic liver damage, inflammation, injury and infections, and malnutrition.
Review of human butyrylcholinesterase structure, function, …
网页A recombinant mutant of BChE that rapidly inactivates cocaine is being developed as a treatment to help recovering cocaine addicts avoid relapse into drug taking. These clinical applications rely on knowledge of the structure, stability, and properties of BChE, information that is reviewed here.
The Role of Butyrylcholinesterase and Iron in the Regulation of ...
网页2021年2月18日 · Our observations indicate that the butyrylcholinesterase (BChE) level seems to be iron-dependent, and reports show that BChE produced by reactive astrocytes can make cognitive functions worse by accelerating the decay of …
Review of human butyrylcholinesterase structure, function, genetic ...
网页2015年4月1日 · Butyrylcholinesterase (BChE) has been studied since the 1940s (Alles & Hawes, 1940). Early work determined that there are two kinds of cholinesterase and that only acetylcholinesterase (AChE) has a critical role in nerve impulse transmission (Hawkins and Gunter, 1946, Mendel and Rudney, 1943).
Butyrylcholinesterase in lipid metabolism: A new outlook
网页2023年5月2日 · Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), cholinesterases, catalyze the breakdown of the neurotransmitter acetylcholine into choline and acetic acid (Rosenberry, 1975).
Butyrylcholinesterase - an overview | ScienceDirect Topics
网页Butyrylcholinesterase (pseudocholinesterase or plasma cholinesterase), located in the plasma and liver, metabolizes SCh into succinylmonocholine, an active metabolite, and choline. It also metabolizes mivacurium, ester-type local anesthetics, and trimethaphan.