【导读】肝细胞癌(HCC)的转移严重威胁着患者的生存。GPR56在恶性肿瘤研究中受到广泛关注，在细胞表面信号传递中起着至关重要的作用。然而，其在HCC中的确切功能仍不明确。近日，华中科技大学黄文杰研究团队在期刊《Cell ...

多年来，科学家们一直认为，从胚胎发育到癌症等一系列惊人的细胞过程中，TGF-β是一种信号蛋白，它只有在摆脱了套索状的“紧身衣”后才能发挥 ...

Among these signals, the TGF-β and HIPPO pathways are critical, functioning as tumor suppressors and regulating liver ...

Moreover, we noticed that ISO treatment effectively suppressed TGF-β-induced epithelial-mesenchymal transition (EMT) and activation of the TGF-β-Smad pathway. Furthermore, we discovered that siTGFBR1 ...

We reported previously that knocking-down protein kinase Cα (PKCα) increased vascular calcification in vitro and in vivo, and crucially, PKCα may exert these effects by increasing pro-calcific ...

The aim of this study was to delineate PI3K/mTOR signalling in response to TGF-β 1 stimulation of primary human lung fibroblasts (HLFs), and to investigate the role of this pathway in TGF-β 1 mediated ...

Conclusions Overexpression of WISP1 in the joint may play an important role in OA pathology via modulation of TGF-β signaling and positive feedback on canonical Wnt signaling. Targeting upstream Wnt ...

This review summarizes the association between the disruption of the BBB and the activation of astrocytes in epilepsy via ...

Dr. Massagué identified the TGF-β receptors, their mechanism of signal transduction, and the central concept of how this pathway controls cell division and developmental fate. He provided a direct ...

"Our findings suggest that activating the PPARβ/δ-AMPK pathway could be an effective ... PPARβ/δ activation inhibits TGF-β-induced cell migration, which is a key indicator of cell activation.