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One leading hypothesis over the last few years has been that the pronounced tumour microenvironment in PDA not only promotes carcinogenesis and tumour progression but also mediates therapeutic ...

Methods We presented an integrative analysis containing single-cell RNA-sequencing, whole-exome sequencing, and bulk RNA-sequencing in SHCC and usual HCC samples from 134 patients, to delineate ...

Stromal Cells. The cellular composition of the microenvironment includes cells of mesenchymal origin (fibroblasts), inflammatory/immune cells, adipocytes and endothelial cells (vascular).

The interaction between myeloid and stromal cells has received considerable attention ... These clinical trials underscore the unique immunoregulatory role of immune checkpoints within the tumor ...

The physical and molecular structure of brain tumors has made treatment difficult in the past. The complex nature of the brain frequently makes full surgery challenging, and the blood-tumor barrier ...

Even as cancer remains a leading cause of death globally, bacteria-based cancer therapy presents an exciting and innovative ...

Scientists are supercharging T cells with multipotent stromal cells’ mitochondria to make them more ferocious invaders of the tumor microenvironment. An international collaboration between researchers ...