It all started in the lab. Two Boston University doctoral students, Joshua McGee and Jack Kirsch, were creating and testing ...

An accidental discovery turned into an unexpected success when a team of interdisciplinary BU researchers created a new and ...

Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising ...

Concerted efforts to deepen understanding of RNA modifications and their role in living systems hold the potential to advance human health, improve crop yields, and address other pressing societal ...

Researchers have discovered RNA mechanisms that may lead to more effective, durable and targeted treatments for conditions like high cholesterol, liver diseases and cancers. RNA interference (RNAi ...

Closing the RNA loop holds promise for more stable, effective RNA therapies. ScienceDaily . Retrieved September 15, 2024 from www.sciencedaily.com / releases / 2024 / 08 / 240826182915.htm ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

The primary function of guanine is to store and transmit genetic information in DNA and RNA. In DNA, guanine is always paired with cytosine, and the sequence of these base pairs determines the genetic ...

RNA转录后修饰，比如m6A, m1A, m5C, 和假尿嘧啶（Ψ）修饰，共同组成了表观转录组，是一种新层次的基因表达调控方式。m6A是mRNA和lncRNA上含量最丰富的修饰，在转录后各个水平影响mRNA/lncRNA 的代谢 ...

They were determined to see if RNA sequences crafted with small changes to their nucleotides ... Douam says that the new vaccine, which incorporates modified nucleotides called m5C (5-methylcytidine), ...