Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising ...

An accidental discovery turned into an unexpected success when a team of interdisciplinary BU researchers created a new and ...

It all started in the lab. Two Boston University doctoral students, Joshua McGee and Jack Kirsch, were creating and testing ...

Douam says that the new vaccine, which incorporates modified nucleotides called m5C (5-methylcytidine), also triggered very low levels of inflammation upon vaccination comparable to mRNA vaccines.

mRNA最常见的内部修饰包括N6-腺苷酸甲基化（m6A）、N1-腺苷酸甲基化（m1A）、胞嘧啶羟基化（m5C）等。 当RNA分子腺苷酸上第六位氮原子处发生甲基化时，就是我们所说的m6A。虽然RNA甲基化的研究在上世纪七十年代就开始，但是由于技术上的局限一直停滞不前。

RNA转录后修饰，比如m6A, m1A, m5C, 和假尿嘧啶（Ψ）修饰，共同组成了表观转录组，是一种新层次的基因表达调控方式。m6A是mRNA和lncRNA上含量最丰富的修饰，在转录后各个水平影响mRNA/lncRNA 的代谢和功能 [1]。此外，m6A还参与了其它ncRNA的功能，例如，调控circRNA非 ...

The central dogma of molecular biology suggests that the primary role of RNA is to convert the information stored in DNA into proteins. In reality, there is much more to the RNA story. However ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

随着UBS-seq的发表，将会进一步促进m5C的生物功能的研究，并和SAC-seq，BID-seq一起引领RNA表观转录组领域步入新的阶段。 中国2型糖尿病（T2DM ...

Whether as a sponsor or donor, a member or volunteer, or an employee or fellow, you can make a difference. Concerted efforts to deepen understanding of RNA modifications and their role in living ...