结肠镜检查是结直肠腺瘤（CRA）诊断的标准方法。但它作为一种侵入性检查，会给患者带来一定的不适感；同时其高昂的操作成本限制了其在大规模筛查中的应用。已有的研究表明使用血浆代谢物进行结直肠癌（CRC）诊断是一种有效可行的方式。然而在腺瘤-癌发展过程中， ...

For many years this was the world that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhabited. Seemingly relegated to serving as a reliable loading control for western blots and other such ...

加入兔二抗（Cat＃KC-RB-035）时同时加入HRP标记的抗GAPDH单抗（稀释比例为1：10,000，Cat＃KC-5G5）。采用化学发光试剂盒（康成生物Cat＃KC-420）及X胶片曝光显影。一次反应即可同时检测目的蛋白（Akt）与内参GAPDH的含量。 右图：A-E分别表示细胞株ELC、U937、HSC、SPCA ...

糖尿病心脏病是糖尿病患者致死的主要原因之一，尤其是在2 型糖尿病患者中。广义的糖尿病心脏病包括冠状动脉粥样硬化性心脏病(冠心病)，糖尿病心肌病和糖尿病心脏自主神经性病变等。 高血糖是 DCM（扩张型心肌病） ...

老人整天催着找媳妇，没想到大哥顿悟了，网友：有格局！

Inhibition of GAPDH activity by hyperglycemia does not occur when mitochondrial overproduction of superoxide is prevented by either UCP-1 or MnSOD. [36] What happens when GAPDH activity is inhibited?

Psoriasis is a multifactorial immune-mediated inflammatory disease. Its pathogenesis involves abnormal accumulation of neutrophils and T-cell related abnormalities. Pyroptosis is a type of regulated ...

This useful study by Gao et al identifies Hspa2 as a heterogeneous transcript in the early embryo and proposes a plausible mechanism showing interactions with Carm1. The authors propose that ...

High resolution deconvolution microscopy-based image of MDA-MB-453 human breast cancer cells simultaneously labeled by immunofluorescence (Her-2, Green), DNA (DAPI, Blue, nucleus) and mRNA FISH ...

A plethora of evidence now supports the role of various host microbiomes in human disease, metabolism, and physiology.