研究人员首先仔细比较了使用BET抑制剂与去除BET蛋白后对转录的影响，并发现 MYC ...

This finding suggests that the regulatory effects of histone acetylation may be exerted by bromodomain-containing proteins. The visibility of bromodomains has been high due to their presence in ...

Hopes were high a decade ago, when a new class of drugs called BET inhibitors emerged for treating blood cancers and solid ...

Further candidates, including inhibitors of acetyl-lysine readers (bromodomain-containing proteins), are undergoing clinical evaluation for efficacy in different cancer settings. Among the various ...

A BET inhibitor blocking the bromodomain of BRD4. This therapy has shown promise, but remains ineffective at treating breast ...

NanoBRET™ 技术是最新型的BRET技术，可实现在活细胞内实时监测蛋白相互作用。 使用NanoBRET技术进行蛋白相互作用研究，通过网页或微信下载NanoBRET分享模板，提供使用心得或数据，即可获得价值200元礼品; 并有机会被邀请成为Promega特约技术讲师，参加Promega举办的 ...

New research has illustrated why a promising cancer drug doesn't work against some breast cancers – and has offered insights ...

Resverlogix Corp. (TSX: RVX) (“Resverlogix” or “the Company”) today announced its presentation at the European Society of ...

–(BUSINESS WIRE)–August 26, 2024– Opna Bio announced that it has dosed the first patient with OPN-6602, a potent and selective EP300/CBP bromodomain inhibitor, in a Phase 1 clinical study in ...