Causes and pathophysiology of Cushing syndrome - UpToDate
网页2024年9月19日 · Cushing syndrome may be caused either by excessive corticotropin (ACTH) production (often called ACTH-dependent Cushing syndrome) or by autonomous adrenal cortisol secretion (often called ACTH-independent Cushing syndrome) (table 1).
Cushing Syndrome - StatPearls - NCBI Bookshelf
网页2023年6月26日 · Pathophysiology. Cortisol is a steroid hormone produced by the zona fasciculata of the adrenal cortex. After production the cortisol is carried to different parts of the body by cortisol binding protein, almost 90% of cortisol binds to this (CBG) protein and has a bioavailability of 60% to 100%.
Cushing Disease - StatPearls - NCBI Bookshelf
网页2023年2月27日 · Cushing disease is an endocrine disorder characterized by excessive adrenocorticotropic hormone (ACTH) production by the anterior pituitary, leading to the release of an excess of cortisol from the adrenal glands.
Cushing's syndrome - Wikipedia
网页The most common cause of Cushing's syndrome is the use of prescribed glucocorticoids to treat other diseases (iatrogenic Cushing's syndrome). Glucocorticoids are used in treatment of a variety of disorders, including asthma and rheumatoid arthritis , and also used for immunosuppression after organ transplants.
Patient education: Cushing syndrome (Beyond the Basics)
网页2023年5月17日 · Cushing syndrome occurs when there is an excess of cortisol, a hormone produced by the adrenal glands (figure 1). Cortisol is a type of hormone called a "glucocorticoid." It has many important functions and is necessary for the body to work properly; however, too much cortisol can cause problems.
Cushing syndrome - Symptoms and causes - Mayo Clinic
网页2023年6月7日 · Too much cortisol can cause some of the main symptoms of Cushing syndrome — a fatty hump between the shoulders, a rounded face, and pink or purple stretch marks on the skin. Cushing syndrome also can cause high blood pressure or bone loss. Sometimes, it can cause type 2 diabetes.
Cushing's syndrome: from physiological principles to diagnosis …
网页2015年2月1日 · This review briefly summarizes the physiological control systems necessary to understand the pathophysiology, diagnosis, differential diagnosis, and treatment of Cushing's syndrome. Only through a thorough understanding of the physiology of the system can one properly diagnose and care for patients with …
Cushing Syndrome - Cushing Syndrome - MSD Manual Professional Edition
网页Cushing disease is Cushing syndrome that results from excess pituitary production of adrenocorticotropic hormone (ACTH) secondary to a pituitary adenoma. Typical symptoms and signs include moon face and truncal …
Cushing's syndrome - The Lancet
网页2023年11月17日 · We highlight the substantial progress in understanding Cushing's syndrome pathophysiology, including novel findings in genetics and epigenetics, complications, and novel pharmacological therapies available for clinical use.
Cushing's Syndrome: Rapid Evidence Review - AAFP
网页Cushing's syndrome is a rare, multisystemic disease caused by chronic exposure to supraphysiologic levels of cortisol. Prolonged hypercortisolism is associated with significant...